Mortality In Older Patients With Hospital-Acquired Bloodstream Infections In ICU Associated With Inadequate Source Control, Study Finds

Infectious Disease Advisor (4/9, Basilio) reports a study found that “inadequate source control is a significant modifiable risk factor of mortality in older adults with hospital-acquired bloodstream infections (BSIs) in the intensive care unit (ICU).” Researchers observed that by day 28, “mortality occurred among approximately half (49.9%) of the” adult patients with hospital-acquired BSI. Notably, there were “no differences in demographics or comorbidities...between survivors and nonsurvivors, and mortality was not attributed to adequacy of empiric antibiotic treatment during the first 24 hours of ICU admission.” However, researchers found that “survivors achieved significantly higher rates of source control,” while nonsurvivors “more commonly received corticosteroids for sepsis or septic shock and kidney replacement therapy at BSI onset.” The study was published in Infectious Diseases and Therapy.