Gastrointestinal Cancer

mCRC QI Proposals

mCRC QI Proposals

Submit your proposal before March 31, 2026

Receive up to $250,000 for your Quality Improvement Project Proposal Focused on Advancing Biomarker Testing in mCRC

ASCP, in collaboration with Pfizer and with participation from the American Society of Clinical Oncology (ASCO), is inviting proposals for pathology-centric Quality Improvement (QI) initiatives aimed at optimizing molecular testing pathways in the management of metastatic colorectal cancer (mCRC). This grant opportunity seeks to fund sustainable projects that improve biomarker testing practices, strengthen targeted therapy selection, and support care teams in implementing patient-centered protocols.

Learn more and submit your project today.

There are significant advances in molecular diagnostics for metastatic colorectal cancer (mCRC), and these have been incorporated into NCCN Guidelines for frontline therapy. Despite such advances and guidelines, there is significant variability in biomarker testing practices and delays in communicating results that continue to hinder optimal patient treatment decision-making. Current protocols for ordering and reporting critical biomarkers are inconsistent across institutions, leading to gaps in diagnostic excellence and frontline therapy alignment with NCCN guidelines.

These challenges result in fragmented workflows, prolonged turnaround times, and insufficient coordination between pathology, laboratory professionals, and oncology teams. Consequently, patients may experience delays in receiving appropriate, evidence-based therapies.

To address these issues, there is an urgent need for collaborative, multidisciplinary initiatives that leverage data-driven approaches to:

Understanding current biomarker testing practices and identifying variation in test ordering protocols.

Addressing communication gaps to ensure timely dissemination of biomarker results to the care team.

Evaluating turnaround times, reporting workflows, and operational efficiency.

Establishing pathways for accelerated molecular diagnostics to support optimal frontline treatment.

Identifying variations across institutions in receiving and integrating biomarker test results into a patient’s Electronic Medical Record (EMR).

Strengthening care team capacity by equipping pathology and laboratory professionals with tools and skills to enhance communication and care coordination enabling oncologists to make informed diagnostic and therapeutic decisions.

ASCP will support collaborative approaches to improve processes and implement changes such as promoting standardized test ordering and reporting practices, providing data analysis, facilitating effective communication between pathology and oncology departments, and supporting the formation of molecular tumor boards to support multi-disciplinary decision-making and personalized patient care.

Best practices and lessons learned from the program will be published in peer-reviewed journals and relevant outlets to ensure broad visibility of your work.

Proposals must be submitted by March 31, 2026, to be considered.

What Grant Proposals Must Include

In order to qualify for up to $250,000 in grant funds, you must outline a QI project that will:

  • Utilize QI Methodology: Employ formal frameworks such as Plan-Do-Study-Act (PDSA) cycles.
  • Multi-disciplinary team: The project team should include all essential care team stakeholders, including oncologists, to ensure meaningful impact and informed decision-making.
  • Conduct a Root Cause Analysis: Identify local barriers to biomarker testing (e.g., workflow inefficiencies, reporting delays, provider knowledge gaps).
  • Implement Targeted Interventions: Design practical solutions such as streamlined ordering processes or enhanced result communication.
  • Track Key Metrics: Monitor outcomes aligned with recognized QI measures (e.g., testing rates, turnaround times, treatment alignment).

Projects should align with evidence-based, patient-centered oncology quality standards and certification/accreditation models.

This grant is available to active ASCP members only.

Submit your proposal before March 31, 2026

RFP FAQ Webinar - Quality Improvement in Molecular Testing Pathways for Metastatic Colorectal Cancer (mCRC) RFP

February 11, 2026 | 11:00 AM CT

This informational webinar is for the ASCP/Pfizer Quality Improvement in Molecular Testing Pathways for Metastatic Colorectal Cancer (mCRC) RFP. During this webinar, we will review the funding opportunity and will have ample time for questions from participants. Join us on February 11 to learn more.

This ASCP quality improvement initiative is funded through a collaboration agreement with Pfizer.