Asymptomatic Carriers Have Higher Risk Of Developing CDI Despite Antibiotic Stewardship, Study Finds

HCP Live (8/11, Brooks) reports a study found that “asymptomatic C difficile carriers have a higher risk of developing CDI, despite antibiotic exposure not significantly increasing this risk among carriers.” Among the study cohort, “exposure to any antibiotic was associated with an increased risk of CDI, with each additional day of exposure to antibiotics having an HR of 1.08. Exposure to piperacillin and tazobactam was associated with increased risk, with each additional day having an HR of 1.13. Further analysis revealed a positive C difficile screening result at admission was associated with a high risk of infection. Among asymptomatic carriers, investigators pointed out antibiotic exposure was not significantly associated with a further increase in CDI hazard.” The study was published in JAMA Network Open.