Multilevel Intervention Increases HPV Vaccination For Most Children, Analysis Finds

July 08, 2025

MedPage Today (7/7, Robertson) reports, “A multilevel intervention involving parent nudges and clinician reports increased human papillomavirus (HPV) vaccination for most children, though not for some of the most marginalized, a post hoc analysis of a cluster randomized trial found.” Researchers observed that “vaccine initiation increased significantly for most children with the intervention except for Black children, and those living in rural settings or in highest deprivation areas by the Area Deprivation Index (ADI).” Furthermore, they found that “vaccine completion also increased significantly for most children, except for those in the highest ADI deprivation quartile.” Researchers concluded, “Our findings indicate that mailing reminder letters to parents and monthly reports to healthcare professionals can improve human papillomavirus vaccination among 11- to 12-year-olds.” The analysis was published in JAMA Network Open.