Potential New Biomarker Associated With Liver Fibrosis Severity In Patients With PBC, Study Finds

Rare Disease Advisor (4/24, Özkaya) reports a study found that “the expression levels of thymocyte differentiation antigen 1 (Thy-1) are associated with the severity of fibrosis in primary biliary cholangitis (PBC).” In the study, researchers observed a “correlation between the expression levels of Thy-1 in the portal areas and the extent of liver fibrosis. They also reported that the sinusoidal expression of Thy-1 aligned with the severity of fibrosis in patients with PBC.” In addition, “the researchers found that the variations in the levels of soluble Thy-1 were in line with the progression of fibrosis from mild to advanced stages in patients with PBC.” They concluded, “The findings suggest that while [soluble] Thy-1 shows potential, its role as a non-invasive biomarker requires further exploration to fully understand its utility in clinical diagnostics.” The study was published in the Journal of Gastroenterology and Hepatology Open.