Serum MCP-1 And Osteopontin Combination May Help Diagnose Early Renal Injury In Patients With Gout, Study Finds

HCPlive (3/20, Johnson) reports, “The combination of serum Monocyte chemoattractant protein-1 (MCP-1) and Osteopontin (OPN) had high diagnostic value of early renal injury in patients with gout, according to new research.” Investigators found that “serum MCP-1 and OPN levels were significantly higher in the gout group compared to controls and further elevated in the early renal injury group.” In addition, “MCP-1 and OPN had positive correlations with creatinine and CysC and a negative correlation with GFR.” Researchers concluded that “serum MCP-1 and OPN levels detected in” patients with gout “are independently associated with early kidney damage, and their combined detection can effectively diagnose early kidney damage with diagnostic efficacy higher than that of either marker alone.” The study was published in the International Journal of General Medicine.