Repeat Serum Protein Electrophoresis (SPEP) testing is discouraged for at least 25 days from the previous result for patients with actively treated disease

For patients with acute or actively treated disease, a minimum retesting interval of 25 days is recommended¹. For patients without actively treated disease, a minimum retesting interval of 3 months is recommended².

Certain high-risk patients with aggressive diseases may warrant more frequent testing. Considering the underlying pathophysiology of monoclonal gammopathies, it is unlikely that SPEP results would change on a weekly basis in most cases³. For most patients who are undergoing active treatments, a monthly monitoring is appropriate³.