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Women With Cystitis Have Higher Risk For Recurrent UTI, Study Shows

Infectious Disease Advisor (8/2, Nye) reported, “Women with cystitis are at higher risk for recurrent urinary tract infection (UTI), particularly those with comorbidities, antibiotic-resistant infections, or a history of frequent antibiotic use and medical encounters,” according to study results. Investigators discovered that “predictors associated with increased risk for recurrent UTI” among women “with cystitis and a positive culture for their index UTI” included Klebsiella positivity, Escherichia coli positivity, and “nonsusceptibility to at least 3 antibiotic classes.” The findings were published in The Journal of Infectious Diseases.

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Approximately One-Quarter Of Men With CF Have Low Testosterone Levels, Study Finds

Cystic Fibrosis News Today (8/2, Lobo) reports that approximately “one-quarter of men with cystic fibrosis (CF) have low testosterone levels, according to a new study.” Investigators found that “neither age nor the time of day when testosterone measurements were taken influenced the levels of the male sex hormone in these patients.” Meanwhile, “testosterone levels were found to correlate with patients’ levels of hemoglobin.” The findings were published in The American Journal of Medical Sciences.

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STI Screening Should Be Included In Diagnostic Workup For Women With PID Who Go To An Emergency Ambulatory Surgical Clinic With Lower Abdominal Pain, Study Shows

Infectious Disease Advisor (8/2, Kuhns) reported, “Screening for sexually transmitted infections (STIs) should be included in the diagnostic workup for young women with pelvic inflammatory disease (PID) who present to an emergency ambulatory surgical clinic with lower abdominal pain, as there is a high incidence of STIs in this in this population,” according to a study. Following “a prospective 12-month cohort pilot study between December 2021 and November 2022 to assess outcomes of a novel STI screening program,” researchers discovered that 57% of patients who tested positive for an STI “reported right iliac fossa pain.” The findings were published in Sexually Transmitted Infections.

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23andMe Rejects CEO’s Take-Private Offer

Reuters (8/2, Roy) reported, “Genetic testing firm 23andMe will not go ahead with CEO Anne Wojcicki’s take-private offer and has asked her to withdraw any plan to oppose any alternative deal, the company said on Friday.” Wojcicki’s “non-binding proposal, disclosed in a regulatory filing on Wednesday,” aimed “to acquire all outstanding shares of 23andMe not already owned by her or her affiliates for $0.40 per share.” The proposal was rejected by “a special committee formed by the company...as it saw the offer as insufficient and not in the best interests of the non-affiliated shareholders.” In its response, the committee “said it was prepared to provide her and potential investors additional time to submit a revised proposal in line with the company’s expectation,” though “other alternatives will be pursued to maximize value for shareholders, in the absence of a revised offer, the panel added.”

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Mpox Cases Increase By 160% In Africa, Report Says

The AP (8/1, Koena, Cheng) says, “The Africa Centers for Disease Control and Prevention said in a report released Wednesday that mpox...has now been detected in 10 African countries this year including Congo, which has more than 96% of all cases and deaths.” Officials “said mpox cases have spiked by 160% so far this year” and “nearly 70% of cases in Congo are in children younger than 15, who also accounted for 85% of deaths.” While previous mpox outbreaks resulted in lesions “on the chest, hands and feet, the new form of mpox causes milder symptoms and lesions mostly on the genitals, making it harder to spot.”

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Traces Of Metals In Urine Were Associated With Increased Risk Of CVD, All-Cause Mortality, Study Finds

MedPage Today (8/1, Lou) reports, “Traces of non-essential and essential metals in urine were associated with increased risk of cardiovascular disease (CVD) and all-cause mortality, according to the largest epidemiological study on the topic to date.” Investigators found, “based on the Multi-Ethnic Study of Atherosclerosis (MESA), individual urinary metals were tied to incident events over more than 17 years when comparing the highest to lowest quartiles: Cadmium: HR 1.25 for CVD (95% CI 1.03-1.53) and HR 1.68 for death (95% CI 1.43-1.96); Tungsten: HR 1.20 for CVD (95% CI 1.01-1.42) and HR 1.16 for death (95% CI 1.01-1.33); Uranium: HR 1.32 for CVD (95% CI 1.08-1.62) and HR 1.32 for death (95% CI 1.12-1.56); Cobalt: HR 1.24 for CVD (95% CI 1.03-1.48) and HR 1.37 for death (95% CI 1.19-1.58); Copper: HR 1.42 for CVD (95% CI 1.18-1.70) and HR 1.50 for death (95% CI 1.29-1.74); Zinc: HR 1.21 for CVD (95% CI 1.01-1.45) and HR 1.38 for death (95% CI 1.20-1.59)” Meanwhile, “increasing levels of the six metals, mixed, were associated with 29% more CVD and 66% more all-cause mortality after accounting for demographic, lifestyle, and clinical risk factors.” The findings were published in Circulation.

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Two Experimental HIV Vaccine Regimens Fail To Lower Infections In Three-Year Trial Compared To Participants Taking A Placebo In Eastern, Southern Africa, Study Shows

Healio (8/1, Feller) reports, “Two experimental HIV vaccine regimens failed to reduce infections in a 3-year trial in eastern and southern Africa compared with participants who were taking a placebo, some of whom were on oral PrEP, according to a study.” Researchers came to this conclusion after assigning “participants randomly into three groups: one group received a combined DNA vaccine (DNA-HIV-PT123) and protein vaccine (AIDSVAX B/E), one received the DNA vaccine, a modified nondividing virus vector (MVA-CMDR) and a protein-based vaccine (CN54gp140), and a placebo group received saline over the course of a four-injection schedule of visits.” The findings were presented at the International AIDS Conference.

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COVID-19 Vaccination Is Associated With Fewer CV Events, Research Finds

TCTMD (8/1, Neale) reports, “Through one, two, or three doses of COVID-19 vaccine, people who receive the shots generally see lower risks of overall arterial and venous thrombotic events, according to a study of nearly 46 million people living in England.” The data indicated that “the incidence of major events like acute MI, acute ischemic stroke, pulmonary embolism, and deep venous thrombosis was either similar or lower after receipt of one of the three vaccines used during the first 2 years of the pandemic in the United Kingdom compared with before or without the shot.” The researchers found that “the differences in risk were mostly larger after the second and booster doses than after the initial dose of each of the vaccines.” The findings were published in Nature Communications.

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Use Of Empiric Broad-Spectrum Antibiotics Has Increased Among Patients With Suspected Community-Onset Sepsis, Including Those Without Evidence Of Antimicrobial-Resistant Pathogens, Study Finds

Infectious Disease Advisor (7/31, Chan) reports, “The use of empiric broad-spectrum antibiotics has increased among patients with suspected community-onset sepsis, including in those with no evidence of antimicrobial-resistant pathogens,” according to a study. Investigators found that “among patients with suspected sepsis, 30,617 (3.4%) had resistant gram-positive pathogens, 38,844 (4.3%) had resistant gram-negative pathogens, and 65,434 (7.3%) had either resistant gram-positive or gram-negative pathogens.” The findings were published in JAMA Network Open.

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CHIP, mCAs Are Each Associated With Increased Risk Of Developing Breast Cancer And Dying From Colorectal Cancer, Study Finds

Cancer Therapy Advisor (7/31, Lawrence) reports, “Clonal hematopoiesis of indeterminate potential (CHIP) and mosaic chromosomal alterations (mCAs) are each associated with an increased risk of developing breast cancer and dying from colorectal cancer, according to research.” Investigators came to this conclusion after analyzing “whole-genome sequencing data from 11,029 women in the Trans-Omics for Precision Medicine cohort of the Women’s Health Initiative study.” The findings were published in Cancer.

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Women With Asymptomatic, Mild COVID-19 Infection At Time Of Frozen Embryo Transfer Experienced No Significant Adverse Early Pregnancy Outcomes, Research Shows

Healio (7/31, Welsh) says, “Women with asymptomatic or mild COVID-19 infection at the time of frozen embryo transfer did not experience significant adverse early pregnancy outcomes, researchers reported.” After conducting “a retrospective analysis of 709 cases of women undergoing frozen embryo transfer from October 2022 to January 2023,” investigators “observed no significant differences in ongoing pregnancy rates, biochemical pregnancy rates and clinical pregnancy rates for uninfected women, women infected 60 days or more before frozen embryo transfer, women infected less than 60 days before frozen embryo transfer or for women infected 0 to 14 days after frozen embryo transfer.” The findings were published in BMC Pregnancy and Childbirth.

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HHS Announces More Than $68 Million In Ryan White HIV/AIDS Funding For Women And Children With HIV

The Managed Healthcare Executive (7/31, Lutton) reports that HHS has “announced...through the Health Resources and Services Administration (HRSA) more than $68 million in Ryan White HIV/AIDS funding to provide care for women and children with HIV.” The “funding will also advance the Biden-Harris Administration’s National HIV/AIDS Strategy, which aims to call attention to the important of reducing HIV infections in the United States 90% by 2030.”

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CDC To Launch Initiative Providing Seasonal Flu Vaccines To Curb Bird Flu Infections In Farm Workers

The Washington Post (7/30, Sun) reports the CDC “is launching a $5 million initiative to provide seasonal flu shots this fall to about 200,000 livestock workers in states hardest hit by the bird flu outbreak.” The Post adds, “Workers on poultry, dairy and pig farms are at greatest risk of being simultaneously exposed to seasonal flu and the H5N1 bird flu that has infected at least 172 dairy herds in 13 states, according to the Department of Agriculture.” Reuters (7/30, Douglas, Steenhuysen) reports the agency “will allocate $5 million to organizations including the National Center for Farmworker Health to educate and train workers on protecting themselves from bird flu, and another $5 million to providing seasonal flu shots to farm workers, [CDC Principal Deputy Director Nirav] Shah said.” CNN (7/30, Christensen) reports the “CDC said with this new initiative, the seasonal flu vaccine will not be mandatory for farm workers.” Instead, “public health officials on a state-level will bring vaccines to workers at local events and to areas where farm workers typically gather.” The AP (7/30, Stobbe) also reports.

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Presence Of Thyroid Autoantibodies May Be Detected As Early As Age 10 Months In Children, Study Shows

Healio (7/30, Monostra) reports, “The presence of thyroid autoantibodies may be detected as early as age 10 months for children, and those positive for both thyroid peroxidase and thyroglobulin autoantibodies have a higher risk for thyroid disease, according to study data.” Investigators “collected data from children with a high genetic risk for type 1 diabetes enrolled in The Environmental Determinants of Diabetes in the Young (TEDDY) study,” with participants attending “clinic visits” and having “serum samples collected every 3 months from birth to age 4 years, and then every 6 months from age 4 to 15 years.” The findings were published in The Journal of Clinical Endocrinology & Metabolism.

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Adults With High Calcium, Oxalate Urinary Levels May Have Greater Risk Of Developing Kidney Stones, Data Show

Healio (7/30, Carter) reports, “Adults with high calcium and oxalate urinary levels may have a greater risk for developing kidney stones, according to data.” Researchers came to this conclusion after analyzing “9,045 24-hour urine collections from 6,217 participants in the Health Professionals Follow-Up Study and Nurses’ Health Studies I and II,” focusing “on urine volume and pH, and concentrations of calcium, citrate, oxalate, potassium, magnesium, uric acid, phosphorus and sodium.” The findings were published in the American Journal of Kidney Diseases.

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Study Finds High TB Prevalence Among Individuals In Close Contact With Patients Infected With Drug-Resistant TB

Infectious Disease Advisor (7/30, McSwiggin) reports, “The prevalence of tuberculosis (TB) is high among individuals in close contact with patients infected with drug-resistant TB, according to study results.” Researchers came to this conclusion after conducting “a systematic review and meta-analysis to evaluate the prevalence of TB among household and nonhousehold contacts of patients with drug-resistant TB infection,” with data for the analysis being “captured from relevant studies published through June 2023.” The findings were published in the Journal of Infection.

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Measles Cases In US Triple From Last Year, CDC Data Show

NBC News (7/26, Bendix) said data released Friday by the CDC show 188 cases of measles “have been reported in 26 states and Washington, D.C. No deaths have been reported, but 93 people have been hospitalized – mostly children under 5 years old.” According to NBC News, “the U.S. has seen 13 measles outbreaks this year,” compared to four in 2023. The CDC’s data show that “around 85% of the people who got measles this year were either unvaccinated or had an unknown vaccination status.” Many of the cases have also “been linked to international travel, meaning the disease was brought into the U.S. by travelers who were infected in other countries.”

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Blood Test Shows High Diagnostic Accuracy In Identifying Alzheimer’s In Patients With Cognitive Symptoms, Researchers Say

The New York Times (7/28, Belluck) says researchers on Sunday “reported that a blood test was significantly more accurate than doctors’ interpretation of cognitive tests and CT scans in signaling” Alzheimer’s disease. The study “found that about 90 percent of the time the blood test correctly identified whether patients with memory problems had Alzheimer’s,” while “dementia specialists using standard methods that did not include expensive PET scans or invasive spinal taps were accurate 73 percent of the time” and “primary care doctors using those methods got it right only 61 percent of the time.” The findings were published in JAMA and presented at the Alzheimer’s Association International Conference. Also reporting is the AP (7/28, Neergaard).

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WHO Will Send More Than 1M Polio Vaccines To Children In Gaza

Reuters (7/26, Farge) reported, “The World Health Organization is sending more than one million polio vaccines to Gaza to be administered over the coming weeks to prevent children being infected after the virus was detected in sewage samples, its chief said on Friday.” Israel’s military also “said on Sunday it would start offering the polio vaccine to soldiers serving in the Gaza Strip after remnants of the virus were found in test samples in the enclave.”

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Cases Of West Nile Virus Rising Earlier In The Year Than Usual, Study Shows

CNN (7/27, Goodman) reported, “A study published in April in the journal Viruses that looked for evidence of past infection in the stored blood of 250 people admitted to the hospital for other reasons found that almost 1 out of every 5 samples had antibodies to West Nile virus.” In 2024, “West Nile activity has picked up earlier than usual,” leaving experts “worried that could mean a blockbuster year for the virus.” While “scientists have developed promising vaccine candidates against West Nile virus” over the years, none have yet made it “to a larger phase 3 study, which would be necessary for licensure by the US Food and Drug Administration.”

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Women With Cystitis Have Higher Risk For Recurrent UTI, Study Shows

Approximately One-Quarter Of Men With CF Have Low Testosterone Levels, Study Finds

STI Screening Should Be Included In Diagnostic Workup For Women With PID Who Go To An Emergency Ambulatory Surgical Clinic With Lower Abdominal Pain, Study Shows

23andMe Rejects CEO’s Take-Private Offer

Mpox Cases Increase By 160% In Africa, Report Says

Traces Of Metals In Urine Were Associated With Increased Risk Of CVD, All-Cause Mortality, Study Finds

Two Experimental HIV Vaccine Regimens Fail To Lower Infections In Three-Year Trial Compared To Participants Taking A Placebo In Eastern, Southern Africa, Study Shows

COVID-19 Vaccination Is Associated With Fewer CV Events, Research Finds

Use Of Empiric Broad-Spectrum Antibiotics Has Increased Among Patients With Suspected Community-Onset Sepsis, Including Those Without Evidence Of Antimicrobial-Resistant Pathogens, Study Finds

CHIP, mCAs Are Each Associated With Increased Risk Of Developing Breast Cancer And Dying From Colorectal Cancer, Study Finds

Women With Asymptomatic, Mild COVID-19 Infection At Time Of Frozen Embryo Transfer Experienced No Significant Adverse Early Pregnancy Outcomes, Research Shows

HHS Announces More Than $68 Million In Ryan White HIV/AIDS Funding For Women And Children With HIV

CDC To Launch Initiative Providing Seasonal Flu Vaccines To Curb Bird Flu Infections In Farm Workers

Presence Of Thyroid Autoantibodies May Be Detected As Early As Age 10 Months In Children, Study Shows

Adults With High Calcium, Oxalate Urinary Levels May Have Greater Risk Of Developing Kidney Stones, Data Show

Study Finds High TB Prevalence Among Individuals In Close Contact With Patients Infected With Drug-Resistant TB

Measles Cases In US Triple From Last Year, CDC Data Show

Blood Test Shows High Diagnostic Accuracy In Identifying Alzheimer’s In Patients With Cognitive Symptoms, Researchers Say

WHO Will Send More Than 1M Polio Vaccines To Children In Gaza

Cases Of West Nile Virus Rising Earlier In The Year Than Usual, Study Shows