Biomarker Panel Can Help Predict Disease Progression In Pediatric Patients With CKD, Study Finds

HealthDay (6/24, Gotkine) reports a study found that “a biomarker panel can improve prediction of chronic kidney disease (CKD) progression in children.” The study involved “children aged 6 months to 16 years with an estimated glomerular filtration rate (eGFR) of 30 to 90 mL/min/1.73 m2.” The participants’ “biomarkers were measured in stored plasma and urine collected five months after enrollment, and a regression tree-based model was constructed using a panel of clinically relevant biomarkers to predict the time to the composite event.” The researchers “found that urine albumin/creatinine was the variable with the highest importance in the final model and, together with urine epidermal growth factor/creatinine, identified the highest risk group of 24 children, of whom 100 percent developed CKD progression at a median of 1.3 years.” The study was published in the Journal of the American Society of Nephrology.