Higher Proteinuria Levels, Lower Baseline eGFR Associated With Adverse Kidney Outcomes In Patients With IgAN, Study Finds

Renal & Urology News (6/11, Persaud) reports a study found that “in patients with immunoglobulin A nephropathy (IgAN), higher levels of proteinuria and lower baseline estimated glomerular filtration rate (eGFR) are strongly associated with adverse kidney outcomes – even at proteinuria levels previously considered low-risk.” Researchers observed that “among 655 patients with IgAN from Kaiser Permanente Southern California health system followed for a median of 3.1 years, 36% reached a composite endpoint of a 50% or greater decline in eGFR, kidney failure, or death.” They noted the “risk for the composite endpoint increased markedly with higher levels of proteinuria.” The findings suggest “that proteinuria of 0.5 g/g or higher, not the traditional 1 g/g or higher threshold, may mark the beginning of heightened risk for disease progression.” The study was published in Nephrology Dialysis Transplantation.