Genetic Analysis Of Postmortem Brains From Individuals In Various Stages Of Alzheimer’s Disease Reveals Two Distinct Phases Of Cell Deterioration

Healio (10/23, Herpen) reports, “A genetic analysis of postmortem brains from individuals in various stages of Alzheimer’s disease revealed two distinct phases of cell deterioration, according to research.” The “analysis revealed two disease-related phases of cell transformation: an early phase marked by a slow increase in disease pathology, presence of inflammatory microglia, reactive astrocytes, loss of somatostatin and inhibitory neurons, along with a remyelination response by oligodendrocyte precursor cells; and a later phase defined by an exponential increase in disease pathology, loss of excitatory neurons and inhibitory neuron subtypes.” The findings were published in Nature Neuroscience.