Researchers Identify Three Distinct Pulmonary Fibrosis Endotypes Through Cluster Analysis Of Blood Biomarkers

Pulmonology Advisor (8/9, Stong) reported, “Three distinct pulmonary fibrosis (PF) endotypes, with differing levels of lung function decline and mortality risk, were identified through a cluster analysis of blood biomarkers, according to study findings.” According to Pulmonology Advisor, “The largest cluster included patients with elevated concentrations of basement membrane collagen neoepitopes (BM cluster; 55%),” while “the second largest cluster comprised patients with high concentrations of epithelial injury biomarkers (EI cluster; 24%), and the smallest cluster included individuals with elevated concentrations of X-FIB (crosslinked fibrin [XF] cluster; 22%).” The findings were published in The Lancet Respiratory Medicine.