Researchers Identify Gene Activity Changes That May Explain Why Motor Nerve Cells Selectively Degenerate In ALS

ALS News Today (7/15, Shapiro) reports, “Researchers have identified gene activity changes that might explain why motor nerve cells selectively degenerate in amyotrophic lateral sclerosis (ALS), offering insights into the development of new therapeutic targets for the neurodegenerative disease.” Researchers found that “in postmortem brain tissue, a particular group of these cells known to be lost in ALS showed greater activity of genes associated with ALS risk, which was accompanied by disruptions in normal protein dynamics.” The findings were published in Nature Aging.