Continuous Beta-Lactam Antibiotic Infusions More Effective At Treating Sepsis Than Intermittent Infusions, Study Finds

Healio (6/14, Hornick) reported, “More ICU patients with sepsis receiving a continuous vs. intermittent infusion of beta-lactam antibiotics achieved clinical cure by day 14, but 90-day mortality was similar, according to research published in JAMA.” In the study, “a slightly lower proportion of patients in the continuous vs. intermittent infusion group died by day 90 (24.9% vs. 26.8%), but the between group absolute difference was not statistically significant (–1.9%; 95% CI, –4.9% to 1.1%).” Nonetheless, researchers wrote “the confidence interval around the effect estimate includes a clinically important benefit.”