Researchers Identify Two Genes As Potential Drivers Of PAH In People With HIV-1 Infection

Pulmonary Hypertension News (4/29, Lobo) reports, “Two genes were identified as potential drivers of pulmonary arterial hypertension (PAH) in people with HIV-1 infection in a bioinformatics study, offering new perspectives to uncover the underlying molecular mechanisms that link HIV infection and PAH.” The article adds, “The genes ISG15 and IFI27 are established hub genes involved in the type I interferon (IFN) response pathway, particularly in monocytes, an immune cell that’s crucial for fighting off infections.” The findings were published in Scientific Reports.