History Of Carbapenem Use, Elevated SOFA Scores Tied To Increased Risk For Third-Generation Cephalosporin-Resistant BSIs Among Children, Study Finds

Infectious Disease Advisor (4/10, Nye) reports, “Children with a history of carbapenem use and elevated pediatric Sequential Organ Failure Assessment (SOFA) scores are at increased risk for third-generation cephalosporin-resistant bloodstream infections (BSIs), according to study findings published in Infection and Drug Resistance.” In the study, “patients with resistance were more likely to have pediatric SOFA scores of at least 2 (33.33% vs 17.83%; P =.007), a history of carbapenem use (39.02% vs 23.26%; P =.010), and a prior BSI diagnosis (21.95% vs 10.08%; P =.016).”