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Influenza Vaccination Reduced Hospitalization Risk In Certain Adults During The 2018 To 2020 Influenza Seasons, Study Finds

Pulmonology Advisor (12/11, Stong) reports, “Influenza vaccination was effective in reducing the risk for influenza-associated hospitalizations in adults aged 50 years and older and in all adults at risk for congestive heart failure or chronic obstructive pulmonary disease exacerbations during the 2018 to 2020 influenza seasons, according to study findings.” The findings were published in Clinical Infectious Diseases.

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Health Workers Detail Errors In Adhering To Infection Prevention Guidance During Peak Of COVID-19

Healio (12/11, Feller) says, “In a survey of health care personnel, one-third of registered nurses and more than one-quarter of physicians reported making at least one error in adhering to guidance for personal protective equipment in the previous 2 weeks.” Additionally, “nurses and physicians were far more likely to report nonadherence than other personnel, and respondents with a higher risk for exposure to SARS-CoV-2 were close to six times more likely to report errors, researchers reported.” Researchers “analyzed responses to surveys from 191 health care personnel...collected between July 2020 and January 2021.” The findings were reported in the American Journal of Infection Control.

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CDC Report Warns That Spread Of Drug-Resistant Infections In Ukraine Represents “Urgent” Threat

CNN (12/8, Howard) said, “Hospitals and health facilities in Ukraine are facing an ‘alarming increase’ of antimicrobial-resistant infections amid the war with Russia, a new report says.” The report, which was published on Friday by the CDC, indicates that the spread of antimicrobial resistance “is an ‘urgent crisis’ in Ukraine that ‘must be addressed.’” HealthDay (12/8, Foster) said, “To fight the growing threat, the latest CDC report noted health officials in the Ukraine will need more training and supplies to help hospitals treating infected patients during the war, as labs have struggled to find the supplies and manpower to test infections for antibiotic resistance.”

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Researchers Identify Gene Mutations That Boost Fertility And Are Also Linked To Bodily Damage Later In Life

The New York Times (12/8, Zimmer) reported that a study bolsters the ideas of American evolutionary biologist George Williams, who believed that “growing old might ... be an inescapable side effect of natural selection.” According to the study, “researchers found hundreds of mutations that could boost a young person’s fertility and that were linked to bodily damage later in life.” The findings were published in Science Advances.

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First-Year College Students Living On Campus And/Or Affiliated With Campus Greek Life Have Increased Risk For Meningococcal Disease, Researchers Say

Healio (12/8, Stulpin) reported, “Researchers determined that first-year college students living on campus and/or affiliated with campus Greek life have an increased risk for meningococcal disease.” The findings were published in Open Forum Infectious Diseases.

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WHO Expresses Concern About Spread Of Mpox In Congo

Reuters (12/8, Rigby) reported that the World Health Organization “is ‘very worried’ about the spread of a severe form of mpox that has killed nearly 600 people, mainly children, in the Democratic Republic of Congo this year, a senior official said.” The DRC “has reported over 13,000 cases in 2023, more than twice as many as during the last peak in 2020, with the disease occurring in almost every province.” According to Reuters, the WHO “is working with the authorities on the response and a risk assessment.”

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CDC Warns Travelers About Potential Risk For Rocky Mountain Spotted Fever

NBC News (12/8, Edwards) reported that the CDC “is warning people who are traveling to the Baja California region of Mexico to watch out for ticks that could spread Rocky Mountain spotted fever.” The travel advisory “comes after a person from San Diego died from the disease.” CNN (12/8, Dillinger) reported, “The CDC is warning health care providers that if a patient has symptoms of Rocky Mountain spotted fever and has recently traveled to northern Mexico, they should consider starting treatment with the antibiotic doxycycline right away, rather than waiting for test results to confirm the condition.”

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RSV Vaccinations Remain Low Among Older Americans

The New York Times (12/9, Span) reported, “So far, only about 15 percent of Americans over 60 have received one of the two new R.S.V. shots,” which the FDA approved in May. Public health officials attribute the low uptake to a general lack of knowledge about the vaccine, as well as low awareness of the virus itself. However, the FDA “estimates that the virus sends 60,000 to 160,000 people over 65 to hospitals each year and causes 6,000 to 10,000 deaths.”

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CDC Issues Alert Regarding Mpox Subtype In Democratic Republic Of The Congo

Reuters (12/7, Santhosh) reports the CDC “issued a health alert on Thursday to notify clinicians and health departments about a deadly type of the mpox virus spreading in the Democratic Republic of the Congo.” The agency “said it was alerting about the possibility of a subtype of the mpox virus called Clade I in travelers who have been in DRC.” Furthermore, “Clade I has not yet been reported in the United States at this time, the CDC added.” CNN (12/7, Musa) also covers the story.

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Study Finds Few Adverse Events Following OPAT Containing Cefazolin And Ceftriaxone Were Identified Using Routine Laboratory Monitoring

Healio (12/7, Stulpin) reports, “Few adverse events following outpatient parenteral antimicrobial therapy containing cefazolin and ceftriaxone were identified using routine laboratory monitoring, leading researchers to say the practice may be ‘excessive.’” According to researchers, “programs could likely safely implement less intensive monitoring strategies than IDSA guidelines currently recommend.” The findings were published in Open Forum Infectious Diseases.

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HIV Vaccine Trial In Africa Halts Early After Preliminary Data Suggest It Would Be Ineffective

Reuters (12/7, Biryabarema, Rigby) reports, “A trial of an experimental HIV vaccine in Uganda, Tanzania and South Africa has been stopped early after preliminary data suggested it would not be effective in preventing infection, according to the trial’s chief investigator.” The trial, which “was testing two different combinations of experimental HIV vaccines,” began in December 2020 and was due to end in 2024.

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Hospital-Associated Infections Declined Significantly At Acute-Care Hospitals In 2022, CDC Report Finds

Healio (12/7, Feller) reports, “Hospital-associated infections declined significantly at acute-care hospitals in 2022, although rates at other health care facilities remained relatively stagnant, according to a CDC report.” However, “even with the progress shown in the 2022 report, the CDC noted that one in 31 patients at health care facilities and one in 43 nursing home residents contracts an HAI each day. The new report, it said, underscores the need for improvement.”

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Children Who Received Two Or More Doses Of COVID-19 Messenger RNA Vaccine Were 40% Less Likely To Be Hospitalized Due To The Disease, Study Finds

Healio (12/7, Weldon) reports, “Children who received two or more doses of COVID-19 messenger RNA vaccine were 40% less likely to be hospitalized or visit an ED due to the disease,” according to a recent study. The findings were published in Morbidity and Mortality Weekly Report.

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3 Questions With Robert Goulart, MD, MASCP

Abstract Not Available

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Oxidative Stress Levels and Dynamic Thiol-Disulfide Balance in Preterm Newborns with Bronchopulmonary Dysplasia

Abstract Not Available

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The new WHO 2022 category of molecularly defined renal carcinomas: Accessible to practicing pathologists

Abstract Not Available

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Despite RSV Vaccine Approval, Majority Of Older Adults Still Unvaccinated

The New York Times (12/6, Blum) reports that this winter “marks the first opportunity to see how the R.S.V. vaccines work for older adults in the real world – provided those at highest risk go get vaccinated.” However, “while cases have been climbing across the country over the past few months, only 14.8 percent of adults 60 and over have been vaccinated against the virus,” according to the CDC. The federal agency “has not issued a blanket recommendation for every person 60 and older to get the shot this year,” but instead, “health officials have said vaccination should be targeted toward people at highest risk of severe illness.”

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Adding Throat Swab Specimen To Nasal Specimen Significantly Increased Sensitivity Of COVID-19 Rapid Antigen Tests, Randomized Clinical Trial Finds

MedPage Today (12/6, Kahn) reports, “Adding a throat swab specimen to a nasal specimen significantly increased sensitivity of COVID-19 rapid antigen tests, whether self-collected or collected by a healthcare worker, a randomized clinical trial showed.” The findings were published in JAMA Network Open.

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Detection Of ctDNA With Assay Linked To Disease Recurrence In Patients With HR-Positive, HER2-Negative Early Breast Cancer, Analysis Finds

OncLive (12/6, Killmurray) reports “detection of circulating tumor DNA (ctDNA) with the SignateraTM assay was associated with disease recurrence in patients with hormone receptor (HR)–positive, HER2-negative, node-positive, high-risk early breast cancer at 24 months post-randomization to treatment with adjuvant abemaciclib (Verzenio) and endocrine therapy, according to an analysis.” The findings were presented at the San Antonio Breast Cancer Symposium.

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M184V/I Mutation May Have Little To No Impact On Virologic Suppression Among Patients With HIV Infection Who Switch To Dolutegravir Plus Lamivudine, Study Finds

Infectious Disease Advisor (12/6) reports, “An M184V/I mutation may have little to no impact on virologic suppression among patients with HIV infection who switch to dolutegravir plus lamivudine, according to study findings.” These findings were published in Open Forum Infectious Diseases.

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Influenza Vaccination Reduced Hospitalization Risk In Certain Adults During The 2018 To 2020 Influenza Seasons, Study Finds

Health Workers Detail Errors In Adhering To Infection Prevention Guidance During Peak Of COVID-19

CDC Report Warns That Spread Of Drug-Resistant Infections In Ukraine Represents “Urgent” Threat

Researchers Identify Gene Mutations That Boost Fertility And Are Also Linked To Bodily Damage Later In Life

First-Year College Students Living On Campus And/Or Affiliated With Campus Greek Life Have Increased Risk For Meningococcal Disease, Researchers Say

WHO Expresses Concern About Spread Of Mpox In Congo

CDC Warns Travelers About Potential Risk For Rocky Mountain Spotted Fever

RSV Vaccinations Remain Low Among Older Americans

CDC Issues Alert Regarding Mpox Subtype In Democratic Republic Of The Congo

Study Finds Few Adverse Events Following OPAT Containing Cefazolin And Ceftriaxone Were Identified Using Routine Laboratory Monitoring

HIV Vaccine Trial In Africa Halts Early After Preliminary Data Suggest It Would Be Ineffective

Hospital-Associated Infections Declined Significantly At Acute-Care Hospitals In 2022, CDC Report Finds

Children Who Received Two Or More Doses Of COVID-19 Messenger RNA Vaccine Were 40% Less Likely To Be Hospitalized Due To The Disease, Study Finds

3 Questions With Robert Goulart, MD, MASCP

Oxidative Stress Levels and Dynamic Thiol-Disulfide Balance in Preterm Newborns with Bronchopulmonary Dysplasia

The new WHO 2022 category of molecularly defined renal carcinomas: Accessible to practicing pathologists

Despite RSV Vaccine Approval, Majority Of Older Adults Still Unvaccinated

Adding Throat Swab Specimen To Nasal Specimen Significantly Increased Sensitivity Of COVID-19 Rapid Antigen Tests, Randomized Clinical Trial Finds

Detection Of ctDNA With Assay Linked To Disease Recurrence In Patients With HR-Positive, HER2-Negative Early Breast Cancer, Analysis Finds

M184V/I Mutation May Have Little To No Impact On Virologic Suppression Among Patients With HIV Infection Who Switch To Dolutegravir Plus Lamivudine, Study Finds