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3 Questions With Robert Goulart, MD, MASCP

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Oxidative Stress Levels and Dynamic Thiol-Disulfide Balance in Preterm Newborns with Bronchopulmonary Dysplasia

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Incidental Finding of Parasitic Infection in a 75 Year Old Male with Persistent Hiccups

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UN Issues Warning About Rising Infectious Diseases In Gaza

The Hill (12/13, Nazzaro) reports, “The United Nations on Tuesday warned of rising infectious diseases in Gaza amid overcrowded living conditions and an overwhelmed health system as Israel continues to wage air and ground attacks against Palestinian militant group Hamas.” The UN Office for the Coordination of Humanitarian Affairs “pointed to the Gaza Health Ministry’s estimate of 360,000 cases of infectious diseases in shelters.” However, “a spokesperson for the Health Ministry, which is controlled by Hamas, said the actual number of cases is believed to be higher.”

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Elevated Lp(a) Levels Linked To Greater Subclinical Interstitial Myocardial Fibrosis, Analysis Finds

TCTMD (12/13, L. Maxwell) reports, “Elevated levels of lipoprotein(a) seem to be associated with greater subclinical interstitial myocardial fibrosis, increased myocardial scar prevalence, and left atrial remodeling by cardiac magnetic resonance, according to a new analysis.” The notion “that an elevated blood marker might be linked to fibrosis formation opens the door to potentially using Lp(a) to guide and develop treatment strategies for” patients with heart failure, “especially those who have heart failure with preserved ejection fraction, according to the authors.” The findings were published in the Journal of the American College of Cardiology.

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mRNA-Based RSV Vaccine Effective For Older Adults, Study Finds

MedPage Today (12/13, Kahn) reports, “Moderna’s mRNA-based RSV vaccine was effective at preventing RSV-associated lower respiratory tract disease in adults ages 60 and older, according to results of the randomized ConquerRSV trial.” The findings were published in the New England Journal of Medicine. Healio (12/13, Stulpin) also covers the story.

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Immunocompromised Individuals Infected With COVID-19 Harbor SARS-CoV-2 Organisms With Higher Genetic Diversity, Study Finds

Infectious Disease Advisor (12/13, Nye) reports, “Immunocompromised individuals infected with COVID-19 harbor SARS-CoV-2 organisms with higher genetic diversity, which may lead to the emergence of new variants,” according to a study. The findings were published in The Journal of Infectious Diseases.

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Dengue Infections Reach New Record In Americas, Caribbean Amid Hotter Temperatures

The AP (12/13, Coto) reports, “Dengue is sweeping across the Western Hemisphere in numbers not seen since record-keeping began more than four decades ago, with experts warning that rising temperatures and rapid urbanization are accelerating the pace of infections.” This year, “a record more than 4 million cases have been reported throughout the Americas and Caribbean ... surpassing a previous record set in 2019.” The rise can be attributed to “poor sanitation and a lack of robust health systems,” although “experts say droughts and floods linked to climate change are causing greater transmission of the virus.”

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Flu Vaccine Efficacy During The 2022-2023 Influenza Season Was ‘Moderate’ But Still Prevented Many Hospitalizations Among Adult Patients, Study Indicates

Healio (12/13, Stulpin) reports, “Influenza vaccine efficacy during the 2022-2023 influenza season was ‘moderate’ but still prevented many health care encounters and hospitalizations among adult patients, researchers determined.” The findings were published in The Journal Of Infectious Diseases.

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One In Five Young Women With Germline BRCA Pathogenic Variants Able To Conceive Within 10 Years Of Invasive Breast Cancer Diagnosis, Study Finds

MedPage Today (12/12, Swift) reports, “One in five young women with germline BRCA pathogenic variants were able to conceive within 10 years of invasive breast cancer diagnosis, and their pregnancies were not associated with adverse maternal prognosis or fetal outcomes, an international retrospective cohort study suggested.” The findings were published in JAMA. Healio (12/12, Welsh) also covers the story.

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ColoSense Multitarget Stool RNA Test Demonstrated High Sensitivity For Detection Of Colorectal Cancer And Advanced Adenoma, Study Finds

Healio (12/12, Burba) reports, “The ColoSense multitarget stool RNA test demonstrated high sensitivity for detection of colorectal cancer and advanced adenoma, notably in individuals aged 45 to 49 years, according to” a study. The findings were published in JAMA.

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Despite mRNA-1273 Vaccination Association With Reduced Incidence Of COVID-19 Infection, Other Factors Beyond Vaccination Status May Influence Infection Risk, Study Finds

Infectious Disease Advisor (12/12, Wei) reports, “Although mRNA-1273 vaccination is associated with reduced incidence of COVID-19 infection, other factors beyond vaccination status may influence infection risk,” according to a study. The findings were published in Open Forum Infectious Diseases.

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B-Cell Depletion Therapy May Be Associated With Poor COVID-19 Outcomes, With Humoral Immune Response Impairment And T-Cell Hyperactivation As Primary Immunologic Features, Study Indicates

Infectious Disease Advisor (12/12, Barowski) reports, “B-cell depletion therapy may be associated with poor COVID-19 outcomes, with humoral immune response impairment and T-cell hyperactivation as the primary immunologic features,” according to a recent study. The findings were published in Infectious Diseases.

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AstraZeneca Purchases RSV Vaccine Developer In $1.1B Deal

Reuters (12/12, Shabong) reports, “AstraZeneca said on Tuesday it had agreed to buy respiratory syncytial virus (RSV) vaccine developer Icosavax in a deal valued at up to $1.1 billion.” Icosavax is said to be “developing a combination vaccine candidate targeting RSV and human metapneumovirus.”

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COVID-19 Hospitalizations, Deaths In Patients With SAIRDs Declined Significantly During The Most Recent Two Years Of The Pandemic, Study Indicates

Healio (12/12, Martin) reports, “Hospitalizations and deaths due to COVID-19 in patients with [systemic] autoimmune rheumatic diseases declined significantly during the most recent 2 years of the pandemic, partly thanks to vaccination among vulnerable populations, according to data.” The findings were published in Clinical Rheumatology.

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Supreme Court Dismisses Rulings On Vaccine Mandates For Federal Employees, Military Personnel

The Hill (12/11, Schonfeld) reports, “The Supreme Court wiped a series of rulings implicating the Biden administration’s vaccine mandates for federal employees and military service members, preventing the decisions from holding the weight of precedent in the future.” In doing so, “the justices sided with the Biden administration Monday in agreeing to set aside the lower rulings after deeming the disputes moot, thus providing a clean legal slate for any future vaccine mandates.”

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Biomarkers May Help Predict Remission Among Patients With Severe Asthma After Anti-IL-5 Therapy, Study Finds

Healio (12/11, Hornick) reports, “Sputum neutrophil percentage and levels of eotaxin-1, IL-5 and eosinophil peroxidase may be used to predict remission among patients with severe asthma 1 year after anti-IL-5 therapy, according to a study.” Researchers found “sputum type 2 markers levels could be surrogate markers of response 1 year after anti-IL-5 treatment.” The findings were published in CHEST.

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In Neonates With Acquired In Utero HIV Infection, Administration Of ART Within 48 Hours Of Life Can Lead To Sustained HIV Virological Suppression By Two Years, Study Finds

MedPage Today (12/11, Kahn) reports, “In neonates with acquired in utero HIV infection, administration of antiretroviral therapy within 48 hours of life can lead to sustained HIV virological suppression by 2 years, a phase I/II proof-of-concept study indicated.” The findings were published in The Lancet HIV.

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Study Finds Test-And-Treat Model For Hepatitis C Virus Infection Among Injection Drug Users, People Experiencing Homelessness Resulted In High Levels Of Treatment Initiation, Completion And Cure

Healio (12/11, Burba) reports a study found “a test-and-treat model for hepatitis C virus infection among injection drug users and people experiencing homelessness resulted in high levels of treatment initiation, completion and cure, and may expand care access to marginalized groups.” The findings were published in JAMA Network Open.

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Illumina Files Registration Statement Over Potential Divestiture Of Grail

Reuters (12/11, Mishra) reports, “Illumina said on Monday it had filed a registration statement with the U.S. securities regulator related to a potential divestiture of Grail, even as it challenges a European Union order to divest the cancer test maker in court.” In October, Illumina “said it would divest Grail in 12 months, according to the terms of the European Commission’s order, if the life sciences company does not win its challenge in court.”

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3 Questions With Robert Goulart, MD, MASCP

Oxidative Stress Levels and Dynamic Thiol-Disulfide Balance in Preterm Newborns with Bronchopulmonary Dysplasia

Incidental Finding of Parasitic Infection in a 75 Year Old Male with Persistent Hiccups

UN Issues Warning About Rising Infectious Diseases In Gaza

Elevated Lp(a) Levels Linked To Greater Subclinical Interstitial Myocardial Fibrosis, Analysis Finds

mRNA-Based RSV Vaccine Effective For Older Adults, Study Finds

Immunocompromised Individuals Infected With COVID-19 Harbor SARS-CoV-2 Organisms With Higher Genetic Diversity, Study Finds

Dengue Infections Reach New Record In Americas, Caribbean Amid Hotter Temperatures

Flu Vaccine Efficacy During The 2022-2023 Influenza Season Was ‘Moderate’ But Still Prevented Many Hospitalizations Among Adult Patients, Study Indicates

One In Five Young Women With Germline BRCA Pathogenic Variants Able To Conceive Within 10 Years Of Invasive Breast Cancer Diagnosis, Study Finds

ColoSense Multitarget Stool RNA Test Demonstrated High Sensitivity For Detection Of Colorectal Cancer And Advanced Adenoma, Study Finds

Despite mRNA-1273 Vaccination Association With Reduced Incidence Of COVID-19 Infection, Other Factors Beyond Vaccination Status May Influence Infection Risk, Study Finds

B-Cell Depletion Therapy May Be Associated With Poor COVID-19 Outcomes, With Humoral Immune Response Impairment And T-Cell Hyperactivation As Primary Immunologic Features, Study Indicates

AstraZeneca Purchases RSV Vaccine Developer In $1.1B Deal

COVID-19 Hospitalizations, Deaths In Patients With SAIRDs Declined Significantly During The Most Recent Two Years Of The Pandemic, Study Indicates

Supreme Court Dismisses Rulings On Vaccine Mandates For Federal Employees, Military Personnel

Biomarkers May Help Predict Remission Among Patients With Severe Asthma After Anti-IL-5 Therapy, Study Finds

In Neonates With Acquired In Utero HIV Infection, Administration Of ART Within 48 Hours Of Life Can Lead To Sustained HIV Virological Suppression By Two Years, Study Finds

Study Finds Test-And-Treat Model For Hepatitis C Virus Infection Among Injection Drug Users, People Experiencing Homelessness Resulted In High Levels Of Treatment Initiation, Completion And Cure

Illumina Files Registration Statement Over Potential Divestiture Of Grail