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Basic Concepts in Predictive Biomarkers for Immuno-Oncology

Basic Concepts in Predictive Biomarkers for Immuno-Oncology

This case-based module will focus on how tumor samples can be used to guide patient therapy. Traditionally therapy directed at c-KIT or HER2 cancer proteins have been determined by immunohistochemical staining of patient tumor samples. Using a similar immunohistochemical based strategy, immuno-oncology based chemotherapy has been direct based upon tumor staining for the PD-L1 protein. Unlike interpreting other predictive immunohistochemical staining, PD-L1 reporting is different between different tumor types. General concepts of the predictive nature, cellular location and reporting of PD-L1 expression will be discussed. Other ideas on future predictive biomarkers for immune oncology will be introduced.

 

The activity offers 1.0 CME, CMLE, or SAMs CME credit.

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The rapid rate of breakthroughs in immuno-oncology (IO) have created newand non-intuitivediagnostic paradigms and testing protocols for cancer. This has led to considerable confusion in the broader pathology and laboratory medicine community about the basic science of IO, as well as a lack of...

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