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Triple Hit B-cell Lymphoma with MYC, BCL2 and BCL6 Rearrangements

Triple Hit B-cell Lymphoma with MYC, BCL2 and BCL6 Rearrangements

Clinical presentation and case summary of a B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma (BCLU) with rearrangements of MYC, BCL2, and BCL6 genes.  The case discussion highlights the literature on cytogenetic “double/triple hit” lymphomas, and reviews the clinical, morphologic, immunophenotypic, and cytogenetic features of BCLU, as well as the appropriate ancillary studies required to characterize these lymphomas.
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Item Details:

Intended Audience: Pathologists, Residents, and Laboratory Professionals

Upon completion of this activity, you will be able to:

  • Identify the morphologic and immunophenotypic features of B-cell lymphomas in which the diagnosis of a so-called “double hit” or “triple hit” lymphoma should be...
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