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Near-Tetraploid Acute Myeloid Leukemia with Extensive Erythrophagocytosis

Clinical presentation and cases summary of a rare variant of AML with distinctive morphologic, immunophenotypic, and cytogenetic features; case discussion highlights the available literature on near tetraploid AML and highlights multiple case reports with similar features.

Intended Audience: Pathologists, Residents, and Laboratory Professionals

Upon completion of this activity, you will be able to:

  • Identify the morphologic and immunophenotypic features associated with near-tetraploid AML in order to distinguish these rare tumors from other pathologic mimics.
  • Distinguish between the cytogenetic features of near-tetraploid leukemia and other leukemias with supernumary chromosomes (e.g. hyperdiploid ALL).
  • Recognize the association between RUNX1 gene translocations and near tetraploid leukemia.
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Back to Near-Tetraploid Acute Myeloid Leukemia with Extensive Erythrophagocytosis