Clinical presentation and cases summary of a rare variant of AML with distinctive morphologic, immunophenotypic, and cytogenetic features; case discussion highlights the available literature on near tetraploid AML and highlights multiple case reports with similar features.
Intended Audience: Pathologists, Residents, and Laboratory Professionals
Upon completion of this activity, you will be able to:
- Identify the morphologic and immunophenotypic features associated with near-tetraploid AML in order to distinguish these rare tumors from other pathologic mimics.
- Distinguish between the cytogenetic features of near-tetraploid leukemia and other leukemias with supernumary chromosomes (e.g. hyperdiploid ALL).
- Recognize the association between RUNX1 gene translocations and near tetraploid leukemia.