Back to A Comprehensive Guide to Prostate Diagnosis
About the Course Author:
Donna E. Hansel, MD, PhD is Chief of the Division of Anatomic Pathology and Professor of Pathology at the University of California San Diego in La Jolla, California.
Pathologists, Residents, Pathologists' Assistants
Upon completion of this course, you will be able to:
- Understand correct protocols for grossing prostate specimens.
- Identify histologic features of a normal prostate gland that can mimic prostate neoplasia.
- Distinguish between small foci of prostate cancer and atypical glands on prostate biopsy.
- Correctly report prostate biopsy specimens, including grading and quantitation of prostate cancer.
- Recognize variants of prostate cancer and use of immunohistochemistry in the differential diagnosis.
- Describe spindle cell and mesenchymal lesions of the prostate.
This course is designed to provide a comprehensive overview of diagnostic prostate pathology. Normal prostate anatomy and histology will be discussed in order to provide a baseline to recognize the diverse histology of the prostate gland components, including several histologic features that can mimic prostate neoplasia. Next, prostate biopsies will be discussed in detail. The course will emphasize the diagnosis of prostate cancer in biopsy specimens, including small foci of prostate cancer, grading and reporting of prostate cancer, and identification of prostate cancer variants. Criteria for atypical prostate glands and intraductal carcinoma will be discussed. We will review radical prostatectomy specimens, including grossing of prostates and associated lymph node dissections, as well as address diagnostic challenges such as categorizing extraprostatic extension and identifying and quantifying positive margin status. Finally, we will review non-epithelial lesions of the prostate, including STUMP and stromal sarcoma and distinguish these lesions from sarcomatoid carcinoma. The role of immunohistochemistry in the diagnosis of prostate lesions will be incorporated when relevant.
Module Titles & Approximate Run Times:
Module 1– Normal Prostate Histology and Non-Neoplastic Variations (36 min)
Module 2– Prostate Biopsy I: Clinical Indications, Grossing , Limited Adenocarcinoma and PIN (40 min)
Module 3– Prostate Biopsy II: Grading, Scoring and Therapy Effects (30 min)
Module 4– Prostate Cancer Variants (37 min)
Module 5– Prostate Cancer on Radical Prostatectomy (33 min)
Module 6– Non-epithelial Lesions Involving the Prostate (25 min)
Total approximate run time: 201 min
ACGME/ABMS Competencies for MOC:
PC, MK, PBL, SBP