"Gains and Losses" in Clinical Genetic Testing: Comparative Genomic Hybridization Microarray Technologies Lead the Way (LabQ 2013)
Author(s):
Brian A Gray, CG(ASCP)CMDLMCM
Description:
Intended Audience: Clinical Scientists, Laboratory Technologist/Scientist (Includes all sub-specialty areas), Students, Pathologist Assistants, Laboratory Directors and Educators.
Upon completion of this activity, you will be able to:
- state the principal concepts of the comparative genomic hybridization microarray (aCGH) technique and the typical targets used to detect genetic causes of human disease.
- list the basic types of genomic changes detectable by aCGH methods.
- describe the significance of different classes of copy number variants (CNVs).
- know the limitations of CNV detection by aCGH testing with respect to the identification of genetic causes of human disease.
- identify appropriate ancillary genetic testing modalities required to characterize specific mechanisms of CNVs identified by aCGH methods, to be used for patient management and family genetic counseling.
You can also purchase LabQ packages by visiting www.ascp.org/LabQ and www.ascp.org/LabQ-P.
