Edward D. Plowey, MD, PhD
Resident, Anatomic Pathology

Raymond E. Felgar, MD, PhD
Associate Professor
Associate Director, Hematopathology Fellowship Program, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennnsylvania

Upon completion of this activity, you will be able to:

• discuss the existence of histiocytic tumors in patients with a history of acute lymphoblastic leukemia.
• describe the clonal relationship between the preceding leukemia and the subsequent histiocytic tumor.
• describe the diagnostic features of histiocytic neoplasms, in particular histiocytic sarcoma.
• delineate the various histologies of histiocytic tumors following acute lymphoblastic leukemia—from clinically benign tumors to aggressive neoplasms.