Juehua Gao, MD, PhD
Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL

LoAnn Peterson, MD
Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL

Beverly Nelson, MD
Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL

Charles Goolsby, PhD
Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL

Yi-Hua Chen, MD
Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL

Keywords: Mantle cell lymphoma; Immunophenotype; Flow cytometry; Ki-67

Upon completion of this activity, you will be able to:

• describe the typical immunophenotype of mantle cell lymphoma.
• recognize immunophenotypic variations of mantle cell lymphoma.
• discuss the importance of evaluating cyclin D1 or CCND1/IgH translocation in the proper morphologic context to rule out mantle cell lymphoma, particularly in small biopsy and “fluid” samples.