Shihui Yu, PhD Department of Pathology, Children’s Mercy Hospitals and Clinics and University of Missouri-Kansas City School of Medicine, Kansas City
Douglas C. Bittel, PhD Section of Medical Genetics and Molecular Medicine, Children’s Mercy Hospitals and Clinics and University of Missouri-Kansas City School of Medicine, Kansas City
Nataliya Kibiryeva, MD Section of Medical Genetics and Molecular Medicine, Children’s Mercy Hospitals and Clinics and University of Missouri-Kansas City School of Medicine, Kansas City
David L. Zwick, MD Department of Pathology, Children’s Mercy Hospitals and Clinics and University of Missouri-Kansas City School of Medicine, Kansas City
Linda D. Cooley, MD, MBA Department of Pathology, Children’s Mercy Hospitals and Clinics and University of Missouri-Kansas City School of Medicine, Kansas City
Keywords: Array-based comparative genomic hybridization; Oligonucleotide; Chromosome abnormality; Copy number variant; Validation
Upon completion of this activity, you will be able to:
This activity meets MOC Part II Lifelong Learning requirements. A self-assessment option is available for pathologists attending this program to earn SAM credits for Maintenance of Certification, Part II Self-Assessment Modules (MOC-SAM) for part of the course.
Applying Lean/Toyota Production System Principles to Improve Phlebotomy Patient Satisfaction and WorkflowThis is a Continuing Education on-line course that describes Lean/Toyota production system principles. Complete a multiple-choice pretest and post test to earn 1 CME/SAM credit.
HPV Vaccine Protein L1 Predicts Disease Outcome of High-Risk HPV+ Early Squamous Dysplastic LesionsThis is a Continuing Education on-line course that defines the role of the L1 capsid protein in the life cycle of human papillomaviruses in squamous epithelium. Complete a multiple-choice pretest and post test to earn 1 CME/SAM credit.
Pilot Study of Linking Web-Based Supplemental Interpretive Information to Laboratory Test ReportsThis is a Continuing Education on-line course that lists the benefits of electronic reference materials linked to laboratory test reports. Complete a multiple-choice pretest and post test to earn 1 CME/SAM credit.
E-Cadherin/β-Catenin and CD10: A Limited Immunohistochemical Panel to Distinguish Pancreatic Endocrine Neoplasm From Solid Pseudopapillary Neoplasm of the Pancreas on Endoscopic Ultrasound–Guided Fine-Needle Aspirates of the PancreasThis is a Continuing Education on-line course that describes the characteristic cytologic features of solid pseudopapillary neoplasm of the pancreas (SPN) and its differential diagnosis. Complete a multiple-choice pretest and post test to earn 1 CME/SAM credit.
Immunophenotypic Variations in Mantle Cell LymphomaThis is a Continuing Education on-line course that describes the typical immunophenotype of mantle cell lymphoma. Complete a multiple-choice pretest and post test to earn 1 CME/SAM credit.
Evaluation of Cell Surface Expression of Phosphatidylserine in Ovarian Carcinoma Effusions Using the Annexin-V/7-AAD Assay: Clinical Relevance and Comparison With Other Apoptosis ParametersThis is a Continuing Education on-line course that describes the principle of the flow cytometry (FCM) annexin-V apoptosis assay. Complete a multiple-choice pretest and post test to earn 1 CME/SAM credit.
Time Trends in Fungal Infections as a Cause of Death in Hematopoietic Stem Cell Transplant Recipients: An Autopsy StudyThis is a Continuing Education on-line course that defines the major fatal complications of hematopoietic stem cell transplantation (HSCT), and in particular the contribution of infections as a cause of death. Complete a multiple-choice pretest and post test to earn 1 CME/SAM credit.
Fine-Needle Aspiration Biopsy of Chondromyxoid Fibroma: An Investigation of Four CasesThis is a Continuing Education on-line course that lists the typical clinical and radiologic aspects of chondromyxoid fibroma. Complete a multiple-choice pretest and post test to earn 1 CME/SAM credit.
Distinct Expression Patterns of CD123 and CD34 on Normal Bone Marrow B-Cell Precursors (“Hematogones”) and B Lymphoblastic Leukemia BlastsThis is a Continuing Education on-line course that discusses the molecular and functional properties of IL-3 receptor and the role of IL-3 in normal maturation of B cells. Complete a multiple-choice pretest and post test to earn 1 CME/SAM credit.
Use of a FLAER-Based WBC Assay in the Primary Screening of PNH ClonesThis is a Continuing Education on-line course that discusses the role of the fluorescent aerolysin (FLAER)-based assay in the detection of paroxysmal nocturnal hemoglobinuria (PNH) clones. Complete a multiple-choice pretest and post test to earn 1 CME/SAM credit.
Extramedullary Plasmacytoma–like Posttransplantation Lymphoproliferative Disorders: Clinical and Pathologic FeaturesThis is a Continuing Education on-line course that describes the typical morphologic and phenotypic findings in plasmacytoma-like posttransplant lymphoproliferative disorders (PTLDs). Complete a multiple-choice pretest and post test to earn 1 CME/SAM credit.
Diabetic Microangiopathy in the Liver: An Autopsy Study of Incidence and Association With Other Diabetic ComplicationsThis is a Continuing Education on-line course that describes the histologic features of diabetic hepatosclerosis. Complete a multiple-choice pretest and post test to earn 1 CME/SAM credit.
Automated Assay for Fondaparinux (Arixtra) on the Dade Behring BCS XPThis is a Continuing Education on-line course that describes the mechanism of anticoagulation by the drug fondaparinux. Complete a multiple-choice pretest and post test to earn 1 CME/SAM credit.
In Situ Evidence of KRAS Amplification and Association With Increased p21 Levels in Non–Small Cell Lung CarcinomaThis is a Continuing Education on-line course that describes the significance of KRAS mutation in non-small cell lung carcinoma (NSCLC). Complete a multiple-choice pretest and post test to earn 1 CME/SAM credit.
Implementation of a Rapid Whole Blood D-Dimer Test in the Emergency Department of an Urban Academic Medical Center: Impact on ED Length of Stay and Ancillary Test UtilizationThis is a Continuing Education on-line course that describes how D-dimer testing should be used in the evaluation of venous thromboembolic disease. Complete a multiple-choice pretest and post test to earn 1 CME/SAM credit.
Postchemotherapy Histiocyte-Rich Pseudotumor Involving the SpleenThis is a Continuing Education on-line course that identifies the clinical, morphologic, and immunohistochemical features of postchemotherapy histiocyte-rich pseudotumor. Complete a multiple-choice pretest and post test to earn 1 CME/SAM credit.
Characterization of c-Maf Transcription Factor in Normal and Neoplastic Hematolymphoid Tissue and Its Relevance in Plasma Cell NeoplasiaThis is a Continuing Education on-line course that explains the steps involved in characterization of protein expression using tissue microarrays and immunohistochemistry. Complete a multiple-choice pretest and post test to earn 1 CME/SAM credit.
Pseudolipomatosis Affects Specimens From Endometrial Biopsies
Effect of Human Papillomavirus on Cell Cycle–Related Proteins p16, Ki-67, Cyclin D1, p53, and ProEx C in Precursor Lesions of Cervical Carcinoma: A Tissue Microarray StudyThis is a Continuing Education on-line course that defines the role of human papillomavirus–induced alterations on cell cycle proteins in cervical carcinogenesis. Complete a multiple-choice pretest and post test to earn 1 CME/SAM credit.
Strict Adherence to a Blood Bank Specimen Labeling Policy by All Clinical Laboratories Significantly Reduces the Incidence of “Wrong Blood in Tube”This is a Continuing Education on-line course that describes the potential impact on patient care of reducing mistransfusion. Complete a multiple-choice pretest and post test to earn 1 CME/SAM credit.
Hematogone Hyperplasia in Copper DeficiencyThis is a Continuing Education on-line course that describes typical clinical presentation and common causes of copper deficiency. Complete a multiple-choice pretest and post test to earn 1 CME/SAM credit.
Acute Lymphoblastic Leukemia With Burkitt-like Morphologic Features and High Myeloperoxidase ActivityThis is a Continuing Education on-line course that describes characteristics of leukemia cells that express lymphoid markers simultaneously with myeloperoxidase. Complete a multiple-choice pretest and post test to earn 1 CME/SAM credit.
Aberrant Expression of CD8 in B-Cell Non-Hodgkin Lymphoma: A Multicenter Study of 951 Bone Marrow Samples With Lymphomatous InfiltrationThis is a Continuing Education on-line course that lists types of B-cell lymphoma in which aberrant expression of T-cell markers may occur. Complete a multiple-choice pretest and post test to earn 1 CME/SAM credit.
Usefulness of Cytokeratin 5/6 and AMACR Applied as Double Sequential Immunostains for Diagnostic Assessment of Problematic Prostate SpecimensThis is a Continuing Education on-line course that discusses the role of immunohistochemistry in the routine assessment of prostate specimens. Complete a multiple-choice pretest and post test to earn 1 CME/SAM credit.
Prognostic Significance of CXCL12 Expression in Patients With Colorectal CarcinomaThis is a Continuing Education on-line course that defines the World Health Organization criteria for the histologic grading of the differentiation of colorectal carcinoma. Complete a multiple-choice pretest and post test to earn 1 CME/SAM credit.
Analysis of Human T-Cell Lymphotropic Virus in CD25+ Anaplastic Large Cell Lymphoma in ChildrenThis is a Continuing Education on-line course that defines the pathologic characteristics of anaplastic large cell lymphomas (ALCL) in children. Complete a multiple-choice pretest and post test to earn 1 CME/SAM credit.
Expression of Hepatocyte Antigen in Small Intestinal Epithelium and AdenocarcinomaThis is a Continuing Education on-line course that describes the pattern of Hep Par1 immunoreactivity in nonneoplastic small intestinal and colonic epithelium. Complete a multiple-choice pretest and post test to earn 1 CME/SAM credit.
Justification of the Change From 10% to 30% for the Immunohistochemical HER2 Scoring Criterion in Breast CancerThis is a Continuing Education on-line course that outlines the protocol for the HER2 fluorescence in situ hybridization (FISH) test. Complete a multiple-choice pretest and post test to earn 1 CME/SAM credit.
Composite Pheochromocytoma: A Clinicopathologic and Molecular Comparison With Ordinary Pheochromocytoma and NeuroblastomaThis is a Continuing Education on-line course that describes the histologic and clinical features of composite pheochromocytoma. Complete a multiple-choice pretest and post test to earn 1 CME/SAM credit.
Acute Fungal Sinusitis: Natural History and the Role of Frozen SectionThis is a Continuing Education on-line course that describes the clinical circumstances in which acute fungal sinusitis occurs. Complete a multiple-choice pretest and post test to earn 1 CME/SAM credit.
Time Study of Clinical and Nonclinical Workload in Pathology and Laboratory MedicineThis is a Continuing Education on-line course that describes a continuous self-reporting mechanism to assist with laboratory workload and staffing allocations. Complete a multiple-choice pretest and post test to earn 1 CME/SAM credit.
Cutaneous Peripheral T-Cell Lymphoma Associated With a Proliferation of B CellsThis is a Continuing Education on-line course that describes complex cases of cutaneous peripheral T-cell lymphoma associated with a proliferation of B-cells (cutaneous PTL-B). Complete a multiple-choice pretest and post test to earn 1 CME/SAM credit.
Protein Expression of Carcinoembryonic Antigen Cell Adhesion Molecules in Benign and Malignant Melanocytic Skin LesionsThis is a Continuing Education on-line course that defines cell adhesion molecules such as members of the carcinoembryonic antigen (CEA) family. Complete a multiple-choice pretest and post test to earn 1 CME/SAM credit.
ASC/SIL Ratio for Cytotechnologists: A Surrogate Marker of Screening SensitivityThis is a Continuing Education on-line course that describes the differences between routine (full) review of negative gynecologic cytology cases and rapid prescreening. Complete a multiple-choice pretest and post test to earn 1 CME/SAM credit.
Complete Absence of KSHV/HHV-8 in Posttransplant Lymphoproliferative Disorders: An Immunohistochemical and Molecular Study of 52 CasesThis is a Continuing Education on-line course that lists the 4 main types of posttransplant lymphoproliferative disorders (PTLDs) as classified by the World Health Organization and how they each relate to the likelihood of being associated with a monoclonal lymphocytic proliferation. Complete a multiple-choice pretest and post test to earn 1 CME/SAM credit.
Immunohistochemical Detection of p63 and XIAP in Thymic Hyperplasia and ThymomasThis is a Continuing Education on-line course that lists the types of cells in the thymus likely to be reactive with antibodies to p63. Complete a multiple-choice pretest and post test to earn 1 CME/SAM credit.
Immunohistochemical Evaluation of Prostate Needle Biopsies Using Saved Interval Sections vs New Recut Sections From the Block: A Prospective ComparisonThis is a Continuing Education on-line course that defines the proportion of prostate needle biopsy specimens in which immunohistochemistry is currently being used in their evaluation, and the proportion of urological pathologists who routinely cut and save interval sections for potential immunohistochemistry. Complete a multiple-choice pretest and post test to earn 1 CME/SAM credit.
Genotypic Intratumoral Heterogeneity in Breast Carcinoma With HER2/neu Amplification: Evaluation According to ASCO/CAP CriteriaThis is a Continuing Education on-line course that defines the American Society of Clinical Oncology/College of American Pathologists criteria for HER2/neu amplification. Complete a multiple-choice pretest and post test to earn 1 CME/SAM credit.
Analysis of Bacterial Detection in Whole Blood–Derived Platelets by Quantitative Glucose Testing at a University Medical CenterThis is a Continuing Education on-line course that discusses the scope of the problem of transfusion-transmitted bacterial infection and its clinical ramifications. Complete a multiple-choice pretest and post test to earn 1 CME/SAM credit.
Issues in Neonatal Cellular AnalysisThis is a Continuing Education on-line course that discusses the developmental hematopoiesis and normal hematologic values in term and preterm neonates and infants. Complete a multiple-choice pretest and post test to earn 1 CME/SAM credit.
EGFR and K-ras Mutations Along the Spectrum of Pulmonary Epithelial Tumors of the Lung and Elaboration of a Combined Clinicopathologic and Molecular Scoring System to Predict Clinical Responsiveness to EGFR InhibitorsThis is a Continuing Education on-line course that defines the probability of response to epidermal growth factor receptor (EGFR) inhibitors in lung cancer based on a combination of clinicopathologic features as well as mutational analysis of EGFR and K-ras. Complete a multiple-choice pretest and post test to earn 1 CME/SAM credit.
The Henry Ford Production System: Reduction of Surgical Pathology In-Process Misidentification Defects by Bar Code–Specified Work Process StandardizationThis is a Continuing Education on-line course that lists aspects of lean manufacturing–based techniques that can be effective in laboratory process redesign. Complete a multiple-choice pretest and post test to earn 1 CME/SAM credit.
Flow Cytometry Can Diagnose Classical Hodgkin Lymphoma in Lymph Nodes With High Sensitivity and SpecificityThis is a Continuing Education on-line course that describes the flow cytometry derived immunophenotype of Hodgkin and Reed Sternberg (HRS) cells in classical Hodgkin lymphoma (CHL). Complete a multiple-choice pretest and post test to earn 1 CME/SAM credit.
Laboratory Medicine Quality Indicators: A Review of the LiteratureThis is a Continuing Education on-line course that identifies and applies standard evaluation criteria for health-related quality indicators/performance measures. Complete a multiple-choice pretest and post test to earn 1 CME/SAM credit.
Combined Small Cell Lung Carcinomas: Genotypic and Immunophenotypic Analysis of the Separate Morphologic ComponentsThis is a Continuing Education on-line course that lists key characteristics of combined small cell lung carcinoma (CSCLC). Complete a multiple-choice pretest and post test to earn 1 CME/SAM credit.
Challenges and Pitfalls of Morphologic Identification of Fungal Infections in Histologic and Cytologic Specimens: A Ten-Year Retrospective Review at a Single InstitutionThis is a Continuing Education on-line course that discusses histopathologic challenges of identification of fungi in tissue sections and cytologic preparations. Complete a multiple-choice pretest and post test to earn 1 CME/SAM credit.
Factitious Biochemical Measurements Resulting From Hematologic ConditionsThis is a Continuing Education on-line course that lists the biochemical artifacts associated with various hematologic conditions. Complete a multiple-choice pretest and post test to earn 1 CME/SAM credit.
Direct Measurement of Free Copper in Serum or Plasma UltrafiltrateThis is a Continuing Education on-line course that lists clinical laboratory tests frequently used to diagnose Wilson disease. Complete a multiple-choice pretest and post test to earn 1 CME/SAM credit.
Epithelioid Sarcoma: A Clinicopathologic and Immunohistochemical Analysis of 106 Cases from the French Sarcoma GroupThis is a Continuing Education on-line course that describes the link between SMARCBI/INI1 suppressor gene and human tumors. Complete a multiple-choice pretest and post test to earn 1 CME/SAM credit.
Neuroendocrine Carcinomas of the Lung: A Critical AnalysisThis is a Continuing Education on-line course that defines criteria for diagnosis of different neuroendocrine tumors of the lung. Complete a multiple-choice pretest and post test to earn 1 CME/SAM credit.
Small B-Cell Neoplasms With Typical Mantle Cell Lymphoma Immunophenotypes Often Include Chronic Lymphocytic LeukemiasThis is a Continuing Education on-line course that lists the phenotypic features used to distinguish chronic lymphocytic leukemia from mantle cell lymphoma and other small B-cell neoplasms by flow cytometry. Complete a multiple-choice test to earn 1 CME credit.
The Role of Multiparameter Flow Cytometry for Detection of Minimal Residual Disease in Acute Myeloid LeukemiaThis is a Continuing Education on-line course that defines what is meant by minimal residual disease (MRD). Complete a multiple-choice test to earn 1 CME credit.
Percentage of Tumor in Prostatectomy Specimens: A Study of American VeteransThis is a Continuing Education on-line course that defines the difference between 2 measures of tumor size in the prostate: absolute tumor volume and percent tumor. Complete a multiple-choice test to earn 1 CME credit.
Burkitt Lymphoma in Brazil Is Characterized by Geographically Distinct Clinicopathologic Features
Impact of Ultrasensitive Cardiac Troponin I Dynamic Changes in the New Universal Definition of Myocardial Infarction
What Causes Discrepancies in HER2 Testing for Breast Cancer?A Japanese Ring Study in Conjunction With the Global Standard
Biochemical Markers for Prediction of Chemotherapy-Induced Cardiotoxicity: Systematic Review of the Literature and Recommendations for Use
CK5 Is More Sensitive Than CK5/6 in Identifying the “Basal-like” Phenotype of Breast Carcinoma
Cytologic Features of Metastatic and Recurrent Melanoma in Patients With Primary Cutaneous Desmoplastic Melanoma
CD23+ Mantle Cell Lymphoma: A Clinical Pathologic Entity Associated With Superior Outcome Compared With CD23– Disease
Collagenous Crystalloids in Myoepithelial Carcinoma: Report of a Case and Review of the Literature
False-Positive Sentinel Lymph Nodes in Breast Cancer Patients Caused by Benign Glandular Inclusions: Report of Three Cases and Review of the Literature
Histopathology of Diaphragm Disease of the Small Intestine: A Study of 10 Cases From a Single Institution
Immunostaining With Antibodies to Desmoglein Provides the Diagnosis of Drug-Induced Pemphigus and Allows Prediction of Outcome
Lessons Learned from Mistakes and Deferrals in the Frozen Section Diagnosis of Bronchioloalveolar Carcinoma and Well-Differentiated Pulmonary Adenocarcinoma: An Evidence-Based Pathology Approach
Lymphocytic Esophagitis: A Chronic or Recurring Pattern of Esophagitis Resembling Allergic Contact Dermatitis
p63 Expression in Olfactory Neuroblastoma and Other Small Cell Tumors of the Sinonasal Tract
Reassessment of the Usefulness of Frozen Section Analysis for Hip and Knee Joint Revisions
Reduced Clinical Severity in a Mutationally Well-Characterized Cohort of Severe Hemophilia With Associated Thrombophilia
Suppurative Inflammation With Microabscess and Pseudocyst Formation Is a Characteristic Histologic Manifestation of Cutaneous Infections With Rapid-Growing Mycobacterium Species
Value of Glypican 3 Immunostaining in the Diagnosis of Hepatocellular Carcinoma on Needle Biopsy
Member Login
.
Gene Patent Class Action Lawsuit Proceeds A judge overseeing the class action lawsuit to determine the constitutionality of gene patenting has allowed the case to proceed despite a request to dismiss by the defendants. more...
Dr. Mark Stoler is New ASCP PresidentMark H. Stoler, MD, FASCP, began his tenure as the president of the American Society for Clinical Pathology during the association’s annual business meeting in October. more...
Pathology and Lab Medicine NewsGet the latest pathology and laboratory medicine news from ASCP's partnership website with Medscape. more...
AJCP Call for AbstractsPresent your research at the premier educational event for pathologists and pathology residents. The AJCP Poster Sessions and Resident Research Symposium competition will take place at the 2009 ASCP Annual Meeting in Chicago, October 29-November 1. The deadline to submit abstracts for both the competition and poster sessions is April 30, 2009. more...
Go to AJCPAmerican Journal of Clinical Pathology is the leading clinical-oriented peer-reviewed pathology and laboratory medicine research journal. more...
Go to LABMEDICINELaboratory Medicine is our monthly periodical dedicated to providing continuing education, career development and new technologies to the entire laboratory community. more...