Yasodha Natkunam, MD, PhD
Department of Pathology, Stanford University School of Medicine, Stanford, CA

Sara Tedoldi, PhD
Leukemia Research Fund Immunodiagnostics Unit, Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, Oxford, England

Jennifer C. Paterson
Leukemia Research Fund Immunodiagnostics Unit, Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, Oxford, England

Shuchun Zhao, MS
Department of Pathology, Stanford University School of Medicine, Stanford, CA

Manuel Rodriguez-Justo, MBChB, MSc
Department of Histopathology, University College London Medical School, London, England

Andrew H. Beck, MD
Department of Pathology, Stanford University School of Medicine, Stanford, CA

Reiner Siebert, MD
Institute of Human Genetics, University Hospital Schleswig-Holstein, Kiel, Germany

David Y. Mason, MD
Leukemia Research Fund Immunodiagnostics Unit, Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, Oxford, England

Teresa Marafioti, MD
Leukemia Research Fund Immunodiagnostics Unit, Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, Oxford, England

Keywords: c-Maf; Plasma cell; Tissue microarray; Myeloma; Immunohistochemistry

Upon completion of this activity, you will be able to:

• understand the steps involved in characterization of protein expression using tissue microarrays and immunohistochemistry.
• describe the tissue expression pattern of c-Maf protein in normal hematopoietic tissues and hematopoietic neoplasms.
• discuss the relevance of c-Maf translocation and c-Maf protein expression in plasma cell neoplasms.