Gabriela Gualco, MD
Consultoria em Patologia, Botucatu, Brazil

Lucimara Chioato, PhD
Consultoria em Patologia, Botucatu, Brazil

Lawrence M. Weiss, MD
Division of Pathology, City of Hope National Medical Center, Duarte, CA

William J. Harrington Jr, MD
University of Miami Miller School of Medicine and Sylvester Cancer Center, Fogarty International Center (AIDS and Tuberculosis Program), Miami, FL

Carlos E. Bacchi, MD
Consultoria em Patologia, Botucatu, Brazil

Keywords:Malignant lymphoma; T-cell lymphoma; Anaplastic large cell lymphoma; HTLV-1; Virus-related lymphomas; CD25; Child

Upon completion of this activity, you will be able to:

• define the pathologic characteristics of anaplastic large cell lymphomas (ALCL) in children.
• cite the role, if any, of the association of ALCL with human T-cell lymphotropic virus and/or Epstein-Barr virus.
• provide guidelines for definitive diagnostic testing for ALCL, including immunophenotyping and cytogenetic approaches.