Holly Burford, MD
Department of Pathology and Laboratory Medicine, University of Alabama at Birmingham

Zubair Baloch, MD, PhD
Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia

Xiuli Liu, MD, PhD
Department of Pathology and Laboratory Medicine, Cleveland Clinic, Cleveland, OH

Darshana Jhala, MD
Department of Pathology and Laboratory Medicine, University of Alabama at Birmingham

Gene P. Siegal, MD, PhD
Department of Pathology and Laboratory Medicine, University of Alabama at Birmingham

Nirag Jhala, MD, MIAC
Department of Pathology and Laboratory Medicine, University of Alabama at Birmingham

Keywords: E-cadherin; β-Catenin; CD10; Pancreatic endocrine neoplasms; Solid pseudopapillary pancreatic neoplasms; Endoscopic ultrasound guidance; Fine-needle aspiration

Upon completion of this activity, you will be able to:

• describe the characteristic cytologic features of solid pseudopapillary neoplasm of the pancreas (SPN) and its differential diagnosis.
• define the demographic profile in which SPN is most often identified.
• list possible methods for obtaining tissue samples from a pancreatic mass.