Pablo Conesa-Zamora, PhD
Pharmacogenetic and Molecular Pathology Group, Santa María del Rosel University Hospital, Cartagena, Spain

Asunción Doménech-Peris, MSc
Clinical Analysis Department, Santa María del Rosel University Hospital, Cartagena, Spain

Francisco J. Orantes-Casado, MSc
Pharmacogenetic and Molecular Pathology Group, Santa María del Rosel University Hospital, Cartagena, Spain

Sebastián Ortiz-Reina, MSc
Pathology Department, Santa María del Rosel University Hospital, Cartagena, Spain

Laura Sahuquillo-Frías, MSc
Clinical Analysis Department, Santa María del Rosel University Hospital, Cartagena, Spain

Jesús Acosta-Ortega, MD
Pathology Department, Santa María del Rosel University Hospital, Cartagena, Spain

José García-Solano, MSc
Pathology Department, Santa María del Rosel University Hospital, Cartagena, Spain

Miguel Pérez-Guillermo, MD, FIAC
Pathology Department, Santa María del Rosel University Hospital, Cartagena, Spain

Keywords: Squamous intraepithelial lesion; Cell cycle; Immunohistochemistry; HPV genotype; Tissue microarray; ProEx C; Cervical cancer; Atypical immature metaplasia

Upon completion of this activity, you will be able to:

• define the role of human papillomavirus–induced alterations on cell cycle proteins in cervical carcinogenesis.
• apply information provided by immunohistochemistry markers for the correct diagnosis of precursor lesions of cervical carcinoma.
• discuss the possible oncogenic potential of atypical immature metaplasia.