Omar Hameed, MBChB
Departments of Pathology and Surgery and the Comprehensive Cancer Center, University of Alabama at Birmingham

Peter A. Humphrey, MD, PhD
Lauren V. Ackerman Laboratory of Surgical Pathology, Department of Pathology and Immunology, Washington University Medical Center, St Louis, MO

Keywords: Prostate; Carcinoma; Immunohistochemistry; α-Methylacyl-CoA racemase; AMACR; p63; Interval sections

Upon completion of this activity, you will be able to:

• define the proportion of prostate needle biopsy specimens in which immunohistochemistry is currently being used in their evaluation, and the proportion of urological pathologists who routinely cut and save interval sections for potential immunohistochemistry.
• list the different prostate needle biopsy sections on which immunohistochemistry can be performed.
• compare the utility of immunohistochemistry performed on saved interval sections of prostate needle biopsy material with that performed on new recut sections from the block.
• identify the most cost-effective prostate needle biopsy sectioning method that can reduce the incidence of noncontributory immunohistochemical stains due to loss of the focus of concern.