Julianne K. Purdy, MD
Department of Pathology, University of Michigan, Ann Arbor, Michigan

Henry D. Appelman, MD
Department of Pathology, University of Michigan, Ann Arbor, Michigan

Christopher P. Golembeski, MD
Department of Pathology, University of Michigan, Ann Arbor, Michigan

Barbara J. McKenna, MD
Department of Pathology, University of Michigan, Ann Arbor, Michigan

Keywords: Lymphocytosis; Esophagitis; Spongiosis; Crohn disease; Allergy

Upon completion of this activity, you will be able to:

• define the range of situations in which intraepithelial lymphocytes may be observed in the esophagus.
• provide wording for the pathology reports of esophageal biopsies in which the major histologic finding is increased intraepithelial lymphocytes.
• provide a brief summary of the literature regarding the significance of intraepithelial lymphocytes.