American Society for Clinical Pathology - Value of Glypican 3 Immunostaining in the Diagnosis of Hepatocellular Carcinoma on Needle Biopsy

Value of Glypican 3 Immunostaining in the Diagnosis of Hepatocellular Carcinoma on Needle Biopsy

Florencia Anatelli, MD
Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri

Shang-Tian Chuang, DO
Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois

Ximing J. Yang, MD, PhD
Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois

Hanlin L. Wang, MD, PhD
Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, California

Keywords: Glypican 3; Liver; Hepatocellular carcinoma; Needle biopsy; Immunohistochemistry

Upon completion of this activity, you will be able to:

list 5 immunohistochemical markers used in differential diagnosis of hepatocellular nodules.
describe the expected pattern of staining seen with antibodies recognizing glypican 3 staining patterns and comparing benign liver nodules to hepatocellular carcinoma.
discuss the diagnostic specificity of an absence of staining of glypican 3 when diagnosing biopsies from liver nodules.

The ASCP designates this educational activity for a maximum of 1 AMA PRA Category 1 Credits™. Physicians should only claim credit commensurate with the extent of their participation n the activities.

This activity meets MOC Part II Lifelong Learning requirements. For MOC brochure, click here.

List Price

$15.00

Member Price

$13.00

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