Arthur Purdy Stout Society Address
Date: Saturday 11:45am-12:45pm
KEY3 Fibrous Dysplasia of Bone: Paradigm Shifting in the Search for Its Pathogenesis
Fibrous dysplasia is one of the most clinically interesting and intensely investigated conditions of bone. While considered a “developmental disorder” throughout most of the 20th century, with the advent of molecular genetics, it is now considered by most to be neoplastic.
Dr. Siegal, immediate past-president of the Arthur Purdy Stout Society of Surgical Pathologists and an active practitioner of diagnostic and experimental pathology, will present an in-depth overview of fibrous dysplasia of bone – including its epidemiology, sites of involvement, and clinical features. Using clinical examples, he will survey our current understanding of its radiologic features, molecular etiology, macroscopy, and histopathology – and touch on immunophenotype, ultrastructural appearance, and postulated cell of origin. He will conclude the presentation with a discussion of differential disease, outcome, and prognostic factors.
Dr. Siegal is a world authority on tumors of bone and related conditions. He holds editorial board positions with multiple journals, including AJCP, and currently serves as Editor in Chief of Laboratory Investigation. His professional honors span four decades and include a fellowship in the Royal Society of Medicine, London, and the sharing of the Farrell Prize from the International Skeletal Society.
Director: Gene P. Siegal, MD, PhD, FASCP
Executive Vice Chair of Pathology, University of Alabama at Birmingham Health System
R. W. Mowry Endowed Professor of Pathology
Director, Division of Anatomic Pathology, University of Alabama at Brimingham